Increased antioxidant enzyme activity in amyloid beta protein-resistant cells
نویسندگان
چکیده
منابع مشابه
Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Alzheimer-disease-associated beta-amyloid (Abeta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (betaAPP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE)/beta-secretase, after which it is cleaved by presenilin (PS)/gamma-secretase near the middle of the transmembrane domain. Thus, inhibition of eithe...
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Several lines of evidence indicate that the Abeta peptide is involved at some level in the pathological process that results in the clinical symptoms of AD (Alzheimer's disease). The N-terminus of Abeta is generated by cleavage of the Met-Asp bond at position 671-672 of APP (amyloid precursor protein), catalysed by a proteolytic activity called beta-secretase. Two 'beta-secretase' proteases hav...
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Background: Schizophrenia has been associated with altered immunity. Different studies regarding natural killer cell activity (NKA) in schizophrenic patients have shown inconsistent results. Objectives: To evaluate NK cell activity in schizophrenic patients in comparison with healthy control individuals. Methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...
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Robert P. ~trosznajder' and Marek ~ a n a s i k ~ " ' ~ e ~ a r t m e n t o f Nei~rophysiology. Medical Research Centre, Polish Academy o f Sciences, 5 Pawinski S t . , 02106 Warsaw. Poland. Email: [email protected]: 'institute o f Environmental Engineering. Polish Academy o f Sciences. 33 M . Curie-Sklodowska St.. 31-8 19 Zabrze. Poland: '~aboratory o f Molecular Clinical Chemistry. Institu...
متن کاملAlternation in Erythrocyte Enzyme Antioxidant Activity during Blood Storage
Background: Blood is permanently exposed to oxidation stress and therefore has a high antioxidants capacity. Many different factors increasing the demand for the antioxidant capacity can be observed in the stored blood of donors. Consequently, damage to erythrocytes by free radicals may occur. So it is useful to control the alternation of anti-oxidant enzymes in stored blood at different days o...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1996
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.16-02-00497.1996